During metabolism, hypoxanthine-guanine phosphoribosyltransferase (HGPRT) transforms 6-mercaptopurine to harmful 6-thioguanine nucleotide analogues, whereas thiopurine methyltransferase (TPMT) deactivates 6-mercaptopurine via methylation to generate 6-methylmercaptopurine. Thiopurine S-methyltransferase (TPMT) is involved in the metabolism of all thiopurines and is one of the primary enzymes that deactivate mercaptopurine. The enzyme responsible for inactivating 6-mercaptopurine (6-MP) is known as hypoxanthine-guanine phosphoribosyltransferase. This enzyme is essential for the metabolism of some compounds, notably 6-MP. Mercaptopurine Dosage is a medication used to treat specific types of cancer, including leukemia. It works by inhibiting the growth and spread of cancer cells. However, before it can be effective, 6-MP must be transformed into an active form within the body. This is where the HGPRT comes in. HGPRT aids in the conversion of 6-MP into active metabolites, which are the forms of medicine that are effective against cancer cells. Without HGPRT, 6-MP cannot be activated and remains dormant in the body.

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