Mitragynine vs 7-Hydroxymitragynine

The two main alkaloids active in kratom (Mitragyna speciosa) and very different in their potency and effects are mitragynine and 7-hydroxymitragynine, respectively. The most abundant alkaloid in the plant is mitragynine, accounting for more than 60% of the alkaloidal profile. It mostly works as a partial mu-opioid receptor agonist, providing mild to moderate analgesia, energy, and mood enhancements.

The second alkaloid, mitragynine vs 7-hydroxymitragynine, is present only in tiny amounts, usually less than 2%. However, it is much more potent. It has the highest affinity for the mu-opioid receptor and affects kratom's pain-relieving and sedation effects to the highest degree. According to some research, 7-OH can be ten times stronger than morphine by weight.

While mitragynine works toward providing a balanced stimulation, 7-OH tends to shift toward a sedative effect. An increase or decrease in their ratio may be what makes a kratom strain either stimulating or sedating.

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